Study M098

Study name

Zheng P 2016a

Title

Metabolite signature for diagnosing major depressive disorder in peripheral blood mononuclear cells

Overall design

In this study, a gas chromatography-mass spectrometry (GC-MS) based metabolomic approach was used to compare peripheral blood mononuclear cells (PBMC) metabolic profiling of 50 first onset drug-naive MDD subjects (depressed group) and 50 healthy controls (control group) as training samples, to identify potential metabolite biomarkers for MDD. An independent sample cohort including 58 MDD patients, 40 schizophrenia patients and 56 healthy controls (test samples) was used to validate diagnostic generalizability and specificity of identified biomarkers.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV-TR diagnosed MDD

Sample size

214

Tissue

Peripheral; Blood; Peripheral blood mononuclear cell;

Platform

MS-based; GC-MS: Agilent 7890A/5975C GC/MS system (Agilent Technologies Inc., USA);

PMID

26874244

DOI

10.1016/j.jad.2016.02.008

Citation

Zheng P, Fang Z, Xu XJ, et al. Metabolite signature for diagnosing major depressive disorder in peripheral blood mononuclear cells. J Affect Disord 2016;195:75-81.

Metabolite

Gamma-Aminobutyric acid;

L-Valine;

L-Isoleucine;

Creatinine;

Hydroxylamine;

Gamma-Tocopherol;

Fumaric acid;

Ethanolamine;

Dopamine;

L-Malic acid;

Sorbitol;

Malonic acid;

Caprylic acid;

Benzoic acid;

L-Homoserine;

Lanosterol;

D-Ribulose 5-phosphate;