Study M097

Study name

Zheng P 2016b

Title

Identification of sex-specific urinary biomarkers for major depressive disorder by combined application of NMR- and GC-MS-based metabonomics

Overall design

Here we combined gas chromatography-mass spectrometry (GC-MS)- and nuclear magnetic resonance (NMR)-based metabonomics to investigate sex differences of urinary metabolite markers in major depressive disorder (MDD), and further explore their potential of diagnosing MDD. The women cohort included 43 first-episode drug-naive MDD patients (depressed women group) and 48 HCs (control women group). The men cohort included 50 first-episode drug-naive MDD (depressed men group) patients and 75 HC (control men group).

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 > 17

Sample size

247

Tissue

Peripheral; Urine; Urine;

Platform

NMR; NMR: Bruker AVANCE II 600 spectrometer (Rheinstetten, Germany);

MS-based; GC-MS: Agilent 7980 GC system with Agilent 5975 mass selective detector (Agilent Technologies Inc., USA);

PMID

27845778

DOI

10.1038/tp.2016.188

Citation

Zheng P, Chen JJ, Zhou CJ, et al. Identification of sex-specific urinary biomarkers for major depressive disorder by combined application of NMR- and GC-MS-based metabonomics. Transl Psychiatry 2016;6(11):e955.

Metabolite

Citric acid;

Pyroglutamic acid;

3-Hydroxybutyric acid;

L-Phenylalanine;

L-Cysteine;

L-Valine;

L-Leucine;

L-Lactic acid;

L-Alanine;

Homovanillic acid;

Hippuric acid;

Succinic acid;

L-Tyrosine;

Azelaic acid;

Pseudouridine;

Oxoglutaric acid;

Indoxyl sulfate;

Hypoxanthine;

Ethanolamine;

Uracil;

Pyruvic acid;

Trimethylamine N-oxide;

Acetic acid;

Glycolic acid;

Trimethylamine;

Methylmalonic acid;

Sucrose;

Sorbitol;

3-Aminoisobutanoic acid;

N-Acetyl-D-glucosamine;

Alpha-Hydroxyisobutyric acid;

4-Deoxyerythronic acid;

Quinolinic acid;

1-Methylinosine;

Acetone;

Isobutyric acid;

Formic acid;

Nicotinic acid;

Malonic acid;

3-Hydroxyphenylacetic acid;

N-Methylnicotinamide;

Ribitol;

Acetamide;

D-Arabitol;

p-Cresol;

2-Ethylhydracrylic acid;

2-Methyl-3-hydroxybutyric acid;