Study M092
Study name | Wu Y 2016 |
Title | Metabolomic analysis reveals metabolic disturbances in the prefrontal cortex of the lipopolysaccharide-induced mouse model of depression |
Overall design | Here, we employed a gas chromatography-mass spectrometry-based metabonomic approach in the lipopolysaccharide (LPS)-induced mouse model of depression to investigate any significant metabolic changes in the prefrontal cortex (PFC). Mice were divided into 2 groups: (1) control group, and (2) LPS group (single dose of LPS intraperitoneal injection at the dose of 0.83 mg/kg). Depressive-like behaviors were then assessed 24 h following the i.p. injection of LPS, and the PFC was separated as soon as the behavioral test was finished. Nine samples in the LPS group and seven samples in the control group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; CD-1 mouse; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 16 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MS-based; GC-MS: Agilent 7890A GC system with Agilent 5975 mass selective detector (Agilent Technologies, Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Wu Y, Fu Y, Rao C, et al. Metabolomic analysis reveals metabolic disturbances in the prefrontal cortex of the lipopolysaccharide-induced mouse model of depression. Behav Brain Res 2016;308:115-27. |
Metabolite | Gamma-Aminobutyric acid; Citric acid; L-Glutamic acid; Arachidonic acid; L-Alanine; L-Asparagine; L-Glutamine; Ascorbic acid; Ethanolamine; Creatine; Cholesterol; Glucose 1-phosphate; 3-Aminoisobutanoic acid; Benzoic acid; N-acetyltryptophan; |
