Study M058
Study name | Hou LJ 2015 |
Title | Urinary metabonomics for diagnosis of depression in Hepatitis B Virus-infected patients |
Overall design | The aim of this study was to investigate the alteration of urinary metabolites in depressed Hepatitis B Virus (HBV)-infected patients. In this study, 81 depressed HBV-infected patients, 68 non-depressed HBV-infected patients and 64 healthy controls were recruited. A nuclear magnetic resonance (NMR)-based urinary metabonomic method was used to characterize the urinary metabolic profiling of depressed and non-depressed subjects. The training set included 3 groups: (1) control group (n = 38), (2) non-depressed HBV-infected group (n = 40), and (3) depressed HBV-infected group (n = 53). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with comorbidity; Depression with comorbidity; |
Criteria for depression | DSM-IV-TR diagnosed MDD, HAMD > 17 |
Sample size | 213 |
Tissue | Peripheral; Urine; Urine; |
Platform | NMR; NMR: Bruker Avance 600 spectrometer; |
PMID | |
DOI | |
Citation | Hou LJ, Wang HW, Wei XX, et al. Urinary metabonomics for diagnosis of depression in Hepatitis B Virus-infected patients. Iran Red Crescent Med J 2015;17(4):e27359. |
Metabolite | 3-Hydroxybutyric acid; Dimethylglycine; Phenylacetylglycine; Pyruvic acid; 2-Hydroxybutyric acid; Acetoacetic acid; Glycolic acid; Trimethylamine; Glycerophosphocholine; Alpha-Hydroxyisobutyric acid; Acetone; |
