Study M044
Study name | Kim SY 2014 |
Title | Chronic repetitive transcranial magnetic stimulation enhances GABAergic and cholinergic metabolism in chronic unpredictable mild stress rat model: 1H-NMR spectroscopy study at 11.7 T |
Overall design | In this study, chronic unpredictable mild stress (CUMS) rat model of depression was used to investigate the behavioral and neurochemical alterations. Furthermore, chronic rTMS treatment effect on neurochemical profile in prefrontal cortex and hippocampus of rats were assessed. The CUMS induced significant reductions in absolute sucrose intake and sucrose preference. In addition, high-resolution 1H-NMR spectra from brain extracts revealed significantly reduced prefrontal and hippocampal GABA levels in CUMS rats compared to control. Rats were divided by four groups (n = 5 in each group): (1) control + sham rTMS group (control with sham rTMS treatment), (2) control + rTMS group (control with rTMS treatment), (3) CUMS + sham rTMS group (stress with sham rTMS treatment), (4) CUMS + rTMS group (stress with rTMS treatment). The CUMS stress procedure lasted for 4 weeks. The rats were treated with daily rTMS for 2 weeks after the model building period. |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Sucrose preference test |
Sample size | 20 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; |
Platform | NMR; NMR: Varian 500 MHz NMR spectrometer; |
PMID | |
DOI | |
Citation | Kim SY, Lee DW, Kim H, et al. Chronic repetitive transcranial magnetic stimulation enhances GABAergic and cholinergic metabolism in chronic unpredictable mild stress rat model: 1H-NMR spectroscopy study at 11.7 T. Neurosci Lett 2014;572:32-7. |
Metabolite |
