Study M042
Study name | He Y 2014 |
Title | Identifying individual differences of fluoxetine response in juvenile rhesus monkeys by metabolite profiling |
Overall design | The aim of this study was to identify biomarkers of response to fluoxetine as well as biomarkers that correlate with impulsivity, a measure of reward delay behavior and potential side effect of the drug, in juvenile male rhesus monkeys. GC-MS was used to identify peripheral metabolite profiling of blood and cerebrospinal fluid (CSF) from animals treated daily with fluoxetine or vehicle for one year. Monkeys were divided into 2 groups (n = 16 in each group): (1) control group and (2) fluoxetine group. Animals were treated orally with fluoxetine or vehicle for one year. Dosing was initiated at 1 year of age at 1.6 mg/kg/d and adjusted to 2.4 mg/kg/d after 11 months. Fluoxetine response metabolite profiles and metabolite/reward delay behavior associations were evaluated using multivariate analysis. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Non-human primate; Rhesus monkey; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 32 |
Tissue | Peripheral; Blood; Plasma; Central; Cerebrospinal fluid; Cerebrospinal fluid; |
Platform | MS-based; GC-MS: Agilent 6890N gas chromatograph (Palo Alto, CA, USA) interfaced to a time-of-flight Pegasus III mass spectrometer (Leco, St. Joseph, MI, USA); |
PMID | |
DOI | |
Citation | He Y, Hogrefe CE, Grapov D, et al. Identifying individual differences of fluoxetine response in juvenile rhesus monkeys by metabolite profiling. Transl Psychiatry 2014;4:e478. |
Metabolite | Myristic acid; Palmitic acid; L-Tryptophan; Arachidonic acid; L-Asparagine; D-Fructose; Urea; Hydroxylamine; Indolelactic acid; 2-Hydroxybutyric acid; Glycolic acid; N-Acetylserotonin; Nicotinic acid; Urea, Polymer With Ethanedial; Parabanic acid; Oxamate; 2,3-Dihydroxypyridine; Shikimic acid; Dehydroascorbic acid; |
