Study M013
Study name | Webhofer C 2011 |
Title | Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation |
Overall design | The aim of this study was to elucidate affected biochemical pathways downstream of monoamine reuptake inhibition by interrogating metabolomic profiles in DBA/2Ola mice after chronic paroxetine treatment. GC-time of flight-mass spectrometry metabolite profiling in the hippocampus of mice after chronic paroxetine treatment was investigated. Mice were divided into 2 groups (n = 6 in each group): (1) control group and (2) paroxetine group. Mice received either paroxetine at 10 mg/kg or vehicle (tap water) twice per day by gavaging for 28 days. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Mouse; DBA/2OlaHsd mouse; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Forced swimming test |
Sample size | 12 |
Tissue | Central; Brain; Hippocampus; Peripheral; Blood; Plasma; |
Platform | MS-based; GC-MS: Agilent 6890N gas chromatograph (Agilent, Palo Alto, CA, USA) interfaced to a time-of-flight Pegasus III mass spectrometer (Leco); |
PMID | |
DOI | |
Citation | Webhofer C, Gormanns P, Tolstikov V, et al. Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation. Transl Psychiatry 2011;1:e58. |
Metabolite | myo-Inositol; Gamma-Aminobutyric acid; L-Valine; L-Leucine; L-Proline; L-Serine; L-Threonine; L-Isoleucine; L-Lactic acid; L-Alanine; L-Tyrosine; D-Fructose; D-Glucose; Threonic acid; |
