Study M001
Study name | Paige LA 2007 |
Title | A preliminary metabolomic analysis of older adults with and without depression |
Overall design | Depressed subjects were treated by a study geriatric psychiatrist using a treatment algorithm. Samples were collected over a three-month period after differing lengths of participation in the study. The authors performed a GC-MS based metabolomic analysis was performed of blood plasma from depressed group (non-remitted patients, MADRS >= 14; n = 9), remitted group (remitted patients, MADRS <= 3; n = 11), and never-depressed older adults (control group; n = 10). Approximately 800 metabolites were analyzed, with comparisons made among the three groups. |
Study Type | Type1; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | NIMH Diagnostic Interview Schedule diagnosed major depression |
Sample size | 30 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; GC-MS: MAT-95 double-focusing magnetic/electric sector mass spectrometer; |
PMID | |
DOI | |
Citation | Paige LA, Mitchell MW, Krishnan KR, et al. A preliminary metabolomic analysis of older adults with and without depression. Int J Geriatr Psychiatry 2007;22(5):418-23. |
Metabolite | Glyceric acid; myo-Inositol; Gamma-Aminobutyric acid; Citric acid; Linoleic acid; Glycerol; Pyroglutamic acid; 4,5-Dihydroorotic acid; Phosphoserine; |
