Study M999
Study name | Zhuang Y 2022 |
Title | Neoagaro-oligosaccharides ameliorate chronic restraint stress-induced depression by increasing 5-HT and BDNF in the brain and remodeling the gut microbiota of mice |
Overall design | The aim of this study was to explore the effects of neoagaro-oligosaccharides on depression and their underlying mechanism in the chronic restraint stress (CRS) model of depression. C57BL/6J mice were divided into the following 5 groups: (1) control group, (2) CRS group, (3) CRS + low dose of neoagaro-oligosaccharides group (chronic restraint stress plus neoagaro-oligosaccharides treatment at the dose of 100 mg/kg), (4) CUMS + high dose of neoagaro-oligosaccharides group (chronic restraint stress plus neoagaro-oligosaccharides treatment at the dose of 200 mg/kg), and (5) CRS + paroxetine group (stressor plus paroxetine treatment at the dose of 10 mg/kg). The mice in the CRS-induced group were repeatedly restrained for 4 h every day for 4 weeks, and drugs were administered via intragastric once per day for 4 weeks after stress. The short-chain fatty acid levels in the cecum contents were obtained by LC-MS analysis (n = 4-5/group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Forced swimming test |
Sample size | 24 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Zhuang Y, Zeng R, Liu X, et al. Neoagaro-oligosaccharides ameliorate chronic restraint stress-induced depression by increasing 5-HT and BDNF in the brain and remodeling the gut microbiota of mice. Mar Drugs. 2022 Nov 18;20(11):725. |
Metabolite |
