Study M996
Study name | Gao L 2021 |
Title | Blockade of indoleamine 2, 3-dioxygenase 1 ameliorates hippocampal neurogenesis and BOLD-fMRI signals in chronic stress precipitated depression |
Overall design | The aim of this study was to investigate the molecular mechanism of indoleamine 2, 3-dioxygenase 1 in depression by using the chronic unpredictable mild stress (CUMS) model. C57BL/6J mice were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 6 weeks. Serum levels of tryptophan, serotonin, and kynurenine were measured using LC-MS (n = 6/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, tail suspension test, forced swimming test |
Sample size | 12 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Agilent 1200 Series LC system (Agilent Technologies, Waldbronn, Germany) with API 4000TM triple quadrupole mass spectrometer (AB Sciex, Darmstadt, Germany); |
PMID | |
DOI | |
Citation | Gao L, Gao T, Zeng T, et al. Blockade of indoleamine 2, 3-dioxygenase 1 ameliorates hippocampal neurogenesis and BOLD-fMRI signals in chronic stress precipitated depression. Aging (Albany NY). 2021 Feb 11;13(4):5875-5891. |
Metabolite |
