Study M994
Study name | Qiao YL 2021 |
Title | Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT1A receptor: insights from transcriptomics |
Overall design | The aim of this study was to investigate anti-depression effect and potential mechanism of Uncaria rhynchophylla extract in the chronic unpredictable mild stress (CUMS) model of depression. C57BL/6 mice were divided into the following 5 groups (n = 8 in each group): (1) control group, (2) CUMS group, (3) Uncaria rhynchophylla extract group (Uncaria rhynchophylla extract treatment at the dose of 100 mg/kg), (4) CUMS + Uncaria rhynchophylla extract group (stressor plus Uncaria rhynchophylla extract treatment at the dose of 100 mg/kg), and (5) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 30 mg/kg). The CUMS stress procedure lasted for 4 weeks, and Uncaria rhynchophylla extract (100 mg/kg, i.g.) and fluoxetine (30 mg/kg, i.p.) were administered from 8th day to 28th day during stress. The concentrations of neurotransmitters in both prefrontal cortex and hippocampus were determined using LC-MS (n = 6-8/group). |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 38 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: AB Sciex Qtrap 5500 LC-MS/MS system (Foster City, CA, USA); |
PMID | |
DOI | |
Citation | Qiao YL, Zhou JJ, Liang JH, et al. Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT1A receptor: insights from transcriptomics. Phytomedicine. 2021 Jan;81:153436. |
Metabolite |
