Study M990
Study name | Lee J 2020 |
Title | Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance |
Overall design | The aim of this study was to test whether the aged gut microbiome alone is sufficient to decrease short-chain fatty acids in the host and produces cognitive decline. C57BL/6 mice were divided into the following 2 groups (n = 11 per group): (1) young microbiota transplant group, and (2) aged microbiota transplant group. Fecal transplant gavages from aged (18-20 months) or young (2-3 months) mice into germ-free mice were initiated at ~3 months of age. Mice with an aged microbiome demonstrated depressive-like behavior over the 3 months following the initial microbiota transplant. Fecal short-chain fatty acids were measured by LC-MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Tail suspension test |
Sample size | 22 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: Agilent LC-QQQ-MS system; |
PMID | |
DOI | |
Citation | Lee J, Venna VR, Durgan DJ, et al. Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance. Gut Microbes. 2020 Nov 9;12(1):1-14. |
Metabolite |
