Study M988
Study name | Son H 2018b |
Title | Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex |
Overall design | The aim of this study was to investigate whether lowered glutamine synthetase activity induces glutamate and glutamine levels changes and depressive behaviors. C57BL/6 mice were divided into the following 2 groups: (1) control group, and (2) methionine sulfoximine group (methionine sulfoximine treatment at the dose of 100 mg/kg, intraperitoneally). Amino acid levels in the mPFC were measured by liquid chromatography mass spectrometry (n = 5/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, tail suspension test |
Sample size | 10 |
Tissue | Central; Brain; Medial prefrontal cortex; |
Platform | MS-based; LC-MS: Agilent 6460 LC-MS/MS system (Agilent, Singapore); |
PMID | |
DOI | |
Citation | Son H, Baek JH, Go BS, et al. Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex. Neuropharmacology. 2018 Dec;143:143-152. |
Metabolite |
