Study M980
Study name | Chen JH 2022 |
Title | Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis |
Overall design | The aim of this study was to investigate metabolic changes in the olfactory bulb of the chronic mild stress (CMS) model using a liquid chromatography-mass spectrometry metabonomic technique. C57BL/6J mice were divided into the following 2 groups: (1) control group, and (2) CMS group. The CMS stress procedure lasted for 4 weeks. Six olfactory bulb samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 12 |
Tissue | Central; Brain; Olfactory bulb; |
Platform | MS-based; LC-MS: Agilent 1290 Infinity LC system (Agilent Technologies, Santa-Clara, California, USA) with AB SCIEX Triple TOF 6600 System (AB SCIEX, Framingham, MA, USA); |
PMID | |
DOI | |
Citation | Chen G, Zhou S, Chen Q, et al. Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis. Front Mol Neurosci. 2022 Oct 10;15:965697. |
Metabolite | L-Tryptophan; D-Glucose; Serotonin; Uric acid; Fructose 6-phosphate; Taurine; Inosine; Sorbitol; Acetone; |
