Study M965
Study name | Wang SY 2022 |
Title | [Study on the fecal metabolomics of CUMS-susceptible and CUMS-resilient rats] |
Overall design | The aim of this study was to characterize the fecal metabolic profiles of chronic unpredictable mild stress (CUMS)-depression and CUMS-resilience rats. Sprague-Dawley rats were divided into the following 3 groups: (1) control group, (2) CUMS depression group (stressed rats with low sucrose preference after stress), and (3) CUMS resilience group (stressed rats with high sucrose preference after stress). The CUMS stress procedure lasted for 4 weeks. Proton nuclear magnetic resonance-based metabolomics was then applied to measure metabolomic changes in fecal samples of the control (n = 6), CUMS depression (n = 6) and CUMS resilience (n = 4) groups. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 16 |
Tissue | Peripheral; Faece; Faece; |
Platform | NMR; NMR: Bruker 600 MHz AVANCE III NMR; |
PMID | |
DOI | |
Citation | Wang S, Wei F, Liu H, et al. [Study on the fecal metabolomics of CUMS-susceptible and CUMS-resilient rats]. Yao Xue Xue Bao. 2022;57(5): 1411-9. (Article in Chinese) |
Metabolite | L-Phenylalanine; L-Valine; L-Leucine; L-Proline; L-Glutamic acid; L-Isoleucine; L-Methionine; L-Lactic acid; L-Alanine; L-Asparagine; L-Aspartic acid; L-Lysine; L-Tyrosine; D-Glucose; L-Arginine; |
