Study M898
Study name | Yuan DZ 2021 |
Title | Serum metabolomics of end-stage renal disease patients with depression: potential biomarkers for diagnosis |
Overall design | The aim of this study was to reveal the pathogenesis and to discover novel peripheral biomarkers for end-stage renal disease patients with depression through metabolomic analysis. Ultra-high-performance liquid chromatography coupled with mass spectrometry was used to explore changes of serum metabolites among healthy controls (control group, n = 12), end-stage renal disease patients with (end-stage renal disease with depression group, n = 17) or without depression (end-stage renal disease without depression group, n = 17). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | HAMD-17 > 17 |
Sample size | 46 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Liquid chromatography with Triple TOF 5600+ (AB SCIEX, USA); |
PMID | |
DOI | |
Citation | Yuan D, Kuan T, Ling H, et al. Serum metabolomics of end-stage renal disease patients with depression: potential biomarkers for diagnosis. Ren Fail. 2021 Dec;43(1):1479-1491. |
Metabolite | N-Acetyl-L-aspartic acid; L-Glutamic acid; Serotonin; Uric acid; Vanylglycol; Phosphoric acid; Thiamine pyrophosphate; LysoPC(22:4); 3-Methyl-2-oxovaleric acid; PA(34:2); Pregnenolone; Gentisic acid; Urocanic acid; 15-HETE; Dihydrothymine; DG(30:1); 5-HEPE; Enkephalin L; Hydroxyphenylacetylglycine; Tetracosanoic acid; N-Desmethylpromazine; Leucylphenylalanine; Bevantolol; Alfuzosin; Cabergoline; Almitrine; Probucol; PG(36:1); CL(i-36:0/18:2); 4-Methylcatechol; 5-ethyl-5-methyl-2,4-oxazolidinedione; 2,5-Furandicarboxylic acid; 2-Phosphoglyceric acid; 1-Hydroxylorcaserin; Propenoylcarnitine; Malaoxon; 5'-O-Desmethyl omeprazole; 17-HDoHE; 6-Thioxanthine 5'-monophosphate; Hydroxylansoprazole; Eletriptan N-oxide; Carboxycelecoxib; Zileuton O-glucuronide; 5'-Deoxy-5-fluorocytidine; Dehydrogenated ticlopidine; Cladribine; 6-Thioguanosine monophosphate; Farnesyl pyrophosphate; Cephapirin; L-3-Phenyllactic acid; Homocitrulline; cyclic 6-Hydroxymelatonin; Desacetyl-nitazoxanide; Deoxyartemsinin; |
