Study M886
Study name | Chen XJ 2022 |
Title | The role of probiotic intervention in regulating gut microbiota, short-chain fatty acids and depression-like behavior in lead-exposed rats |
Overall design | The aim of this study was to observe the depression-like behavior changes of rats exposed to lead with or without probiotic intervention, and to investigate changes in the gut microbiota and fecal short-chain fatty acids levels after lead exposure. Sprague-Dawley rats were divided into the following 3 groups (n = 15 in each group): (1) control group, (2) lead-exposed group, and (3) lead-exposed + probiotics group. Lead-exposed rats were exposed to a 300 mg/l lead acetate solution for 24 weeks. Probiotics (freeze-dried powder containing Lactobacillus and Bifdobacterium, 1.2x10*9 CFU combined strains, 5 times a week) were administered by gavage in weeks 17-24. The levels of fecal short-chain fatty acids were detected using gas chromatography (n = 6/per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 18 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: not reported; |
PMID | |
DOI | |
Citation | Chen X, Meng S, Yu Y, et al. The role of probiotic intervention in regulating gut microbiota, short-chain fatty acids and depression-like behavior in lead-exposed rats. Int J Occup Med Environ Health. 2022 Feb 15;35(1):95-106. |
Metabolite |
