Study M877
Study name | Pinson MR 2021 |
Title | Disturbances in branched-chain amino acid profile and poor daily functioning in mildly depressed chronic obstructive pulmonary disease patients |
Overall design | The aim of this study was to examine whether depressed chronic obstructive pulmonary disease (COPD) patients have certain clinical/functional features. Seventy-eight outpatients with moderate to severe COPD were stratified based on presence of depression using a validated questionnaire. The COPD depressed (depressed COPD group, n= 27) patients on average had mild depression compared to the non-depressed COPD patients (COPD group, n= 51). Plasma amino acid concentrations of the essential amino acids, tryptophan, large neutral amino acids, and the branched-chain amino acids were analyzed batch-wise by LC-MS/MS by isotope dilution. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Hospital Anxiety and Depression Scale depression subsection score >= 8 |
Sample size | 78 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Pinson MR, Deutz NEP, Harrykissoon R, et al. Disturbances in branched-chain amino acid profile and poor daily functioning in mildly depressed chronic obstructive pulmonary disease patients. BMC Pulm Med. 2021 Nov 7;21(1):351. |
Metabolite |
