Study M873
Study name | Li Y 2021 |
Title | Integrated network pharmacology and GC-MS-based metabolomics to investigate the effect of Xiang-Su volatile oil against menopausal depression |
Overall design | The aim of this study was to investigate the pharmacological mechanism of Xiang-Su volatile oil against menopausal depression through network pharmacology and metabolomics. Antidepressant-like effect of Xiang-Su volatile oil was validated in menopausal rats by ovariectomy combined with chronic unpredictable mild stress (CUMS). Sprague-Dawley rats were divided into the following 3 groups: (1) control group (pseudo-operation), (2) ovariectomy + CUMS group, and (3) ovariectomy + CUMS + Xiang-Su volatile oil group. Bilateral ovariectomy was performed in the rats (day 0), then rats received CUMS and Xiang-Su volatile oil (97.2 mg/kg, gastric perfusion once daily) from day 15 to day 28. GC-MS-based non-targeted plasma metabolomics were employed to validate the antidepressant effect of Xiang-Su volatile oil (n = 8-10/per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 27 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; GC-MS: Agilent GC 7890B-7000C system (Agilent Technologies Company, United States); |
PMID | |
DOI | |
Citation | Li Y, Yang X, Chen S, et al. Integrated network pharmacology and GC-MS-based metabolomics to investigate the effect of Xiang-Su volatile oil against menopausal depression. Front Pharmacol. 2021 Dec 2;12:765638. |
Metabolite | Stearic acid; L-Tryptophan; L-Valine; L-Proline; L-Serine; L-Threonine; L-Lactic acid; L-Alanine; L-Asparagine; L-Glutamine; L-Lysine; L-Tyrosine; |
