Study M872
Study name | Li HN 2021 |
Title | Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat |
Overall design | The aim of this study was to investigated whether rifaximin protects against stress-induced inflammation and depression-like behaviors by regulating the abundance of fecal microbial metabolites and the microglial functions in the chronic unpredictable mild stress (CUMS) model of depression. Sprague-Dawley rats were divided into the following 4 groups (n = 14 in each group): (1) control group, (2) rifaximin group, (3) CUMS group, and (4) CUMS + rifaximin group (stressor plus rifaximin treatment). The CUMS stress procedure lasted for 4 weeks, and rifaximin (150 mg/kg) was administered by oral gavage once daily during the model building period. Short-chain fatty acids contents (acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid and caproic acid) were measured in the serum and brain by gas chromatography-mass spectrometer (n = 4/per group). |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 16 |
Tissue | Central; Brain; Brain; Peripheral; Blood; Serum; |
Platform | MS-based; GC-MS: Thermo TRACE 1310-ISQ system (Thermo, USA); |
PMID | |
DOI | |
Citation | Li H, Xiang Y, Zhu Z, et al. Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat. J Neuroinflammation. 2021 Nov 4;18(1):254. |
Metabolite |
