Study M865
Study name | Drivsholm N 2021 |
Title | Alterations in the kynurenine pathway of tryptophan metabolism are associated with depression in people living with HIV |
Overall design | The aim of this study was to investigate possible associations between alterations in the kynurenine pathway of tryptophan metabolism and the presence of depression in a predominantly well-treated people living with HIV population. Depression was defined as a diagnosis of depression according to the Major Depression Inventory (2 or 3 core symptoms with a score >= 4 plus at least 2 minor symptoms with a score >= 3) and/or current use of antidepressive medications. A total of 909 people living with HIV were recruited, including 100 people with depression (HIV with depression group) and 809 without depression (HIV without depression group). Plasma samples were used for the quantification of tryptophan, kynurenine, quinolinic acid, and kynurenic acid concentrations using liquid chromatography-tandem mass spectrometry. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Major Depression Inventory (2 or 3 core symptoms with a score >= 4 plus at least 2 minor symptoms with a score >= 3) and/or current use of antidepressive medications |
Sample size | 909 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Drivsholm N, Knudsen AD, Faurholt-Jepsen M, et al. Alterations in the kynurenine pathway of tryptophan metabolism are associated with depression in people living with HIV. J Acquir Immune Defic Syndr. 2021 Jun 1;87(2):e177-e181. |
Metabolite |
