Study M818
Study name | Ait Tayeb AEK 2021 |
Title | Plasma acetyl-L-carnitine and L-carnitine in major depressive episodes: a case-control study before and after treatment |
Overall design | The aims of the current study were to compare the plasma levels of L-carnitine and acetyl-L-carnitine, and the L-carnitine/acetyl-L-carnitine ratio in patients with a current major depressive episode and healthy controls, and to assess their changes after antidepressant treatment. L-Carnitine and acetyl-L-carnitine levels and the carnitine/acetyl-L-carnitine ratio were measured in 460 patients with a major depressive episode in a context of major depressive disorder (MDD group) and in 893 healthy controls (control group). Depressed patients were reassessed after 3 and 6 months of antidepressant treatment for biology and clinical outcome. |
Study Type | Type1; Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR-diagnosed major depressive disorder, HAMD-17 >= 18 |
Sample size | 1353 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: ACQUITY UPLC I Class system (Waters Corporation, Milford, MA, USA) with API 4000 Q-TRAP mass spectrometer (AB Sciex, Darmstadt, Germany); |
PMID | |
DOI | |
Citation | Ait Tayeb AEK, Colle R, El-Asmar K, et al. Plasma acetyl-L-carnitine and L-carnitine in major depressive episodes: a case-control study before and after treatment. Psychological Medicine. 2021 Oct 14:1-10. |
Metabolite |
