Study M808
Study name | Nieoczym D 2021 |
Title | Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies |
Overall design | The aim of this study was to evaluate the effect of pterostilbene in the pentetrazol-induced kindling model of epilepsy in mice as well as to assess some possible mechanisms of its anticonvulsant action in this model. Swiss mice were divided into the following 2 groups: (1) control group, and (2) pentetrazol group. To induce kindling, mice were treated i.p. with pentetrazol at a subconvulsive dose of 35 mg/kg. Pentetrazol administration was repeated three times a week with intervals of at least 48 h. Animals received 21 injections of pentetrazol, while the normal control group (non-kindled) obtained 21 applications of saline. Twenty-four hours after the last pentetrazol injection, locomotor activity, anxiety- and depression-like behavior were assessed in pentetrazol-kindled mice and, after that, animals were decapitated to collect brain structures. GABA and glutamate concentrations in the prefrontal cortex and hippocampus of the pentetrazol-kindled mice were measured using LC-MS/MS method (n = 6 per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; Swiss mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 12 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Excion LC AC HPLC system with Sciex QTRAP 4500 triple quadrupole mass spectrometer; |
PMID | |
DOI | |
Citation | Nieoczym D, Socała K, Zelek-Molik A, et al. Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies. Psychopharmacology. 2021 Aug 1. |
Metabolite |
