Study M799
Study name | Song XM 2021 |
Title | Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder |
Overall design | The aim of this study was to fill that gap by combining psychophysical investigation of visual perception with measurement of GABA concentration in middle temporal visual area (hMT+) in acute depressed major depressive disorder (MDD). Adult MDD subjects (MDD group, n = 18) and age- and gender-matched healthy subjects (control group, n = 20) participated in the spatial suppression psychophysical and 7T proton magnetic resonance spectroscopy experiments. The hMT+ VOIs were placed in the ventrolateral occipital lobe. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-V diagnosed MDD, HAMD-17 >= 18 |
Sample size | 38 |
Tissue | Central; Brain; Middle temporal visual area; |
Platform | MRS; MRS: 7T whole body MR system (Siemens Healthcare, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Song XM, Hu XW, Li Z, et al. Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder. Mol Psychiatry. 2021 Apr 16. |
Metabolite | myo-Inositol; |
