Study M797
Study name | Singh B 2021 |
Title | A preliminary study of the association of increased anterior cingulate gamma-aminobutyric acid with remission of depression after ketamine administration |
Overall design | In this study, seven patients with treatment-resistant depression enrolled in an open-label, feasibility trial of a single IV 40-min ketamine infusion during a functional MR spectroscopy scan utilizing a novel frequency adjusting MEGA-PRESS sequence. Patients were divided into remitters (remitter group; MADRS score =< 9; n = 3) and non-remitters (non-remitter group; n = 4) at 24 hours post-infusion. Dynamic changes of GABA, Glu, and Glx in the anterior cingulate cortex was detected during the ketamine infusion. Metabolite quantification was reported in institutional units. |
Study Type | Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-5 diagnosed MDD, PHQ-9 >= 15 |
Sample size | 7 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 3T Siemens MRI scanner (Siemens Medical Solutions USA, Inc., Malvern, Pennsylvania, USA); |
PMID | |
DOI | |
Citation | Singh B, Port JD, Voort JLV, et al. A preliminary study of the association of increased anterior cingulate gamma-aminobutyric acid with remission of depression after ketamine administration. Psychiatry Res. 2021 Jul;301:113953. |
Metabolite | Gamma-Aminobutyric acid; Creatine; Choline-containing compounds; |
