Study M791
Study name | Lv M 2021 |
Title | A combination of cecum microbiome and metabolome in CUMS depressed rats reveals the antidepressant mechanism of traditional Chinese medicines: a case study of Xiaoyaosan |
Overall design | The aim of this study was to explore the underlying mechanism of the anti-depressant effects of Xiaoyaosan from the perspective of cecal microbiota and metabolites. The chronic unpredictable mild stress (CUMS) depression model was constructed. Sprague-Dawley rats were divided into the following 3 groups (n = 6 in each group): (1) control group, (2) CUMS group, and (3) CUMS + Xiaoyaosan group (stressor plus Xiaoyaosan treatment at the dose of 46.3 g/kg/day). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via intragastric once per day during the model building period. Six cecum samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Peripheral; Gut; Cecum; |
Platform | NMR; NMR: Bruker AVIII 600 MHz NMR spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Lv M, Wang Y, Qu P, et al. A combination of cecum microbiome and metabolome in CUMS depressed rats reveals the antidepressant mechanism of traditional Chinese medicines: a case study of Xiaoyaosan. J Ethnopharmacol. 2021 Aug 10;276:114167. |
Metabolite | Glycerol; L-Phenylalanine; L-Valine; L-Leucine; L-Proline; L-Glutamic acid; Glycine; L-Threonine; L-Isoleucine; L-Methionine; L-Lactic acid; L-Alanine; L-Asparagine; |
