Study M782
Study name | Ironside M 2021 |
Title | Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation |
Overall design | The aim of this study was to investigate the role of the inhibitory neurotransmitter GABA in stress circuitry in females with current and remitted MDD. Multimodal imaging data were analyzed from 49 young female adults across three groups. Nineteen participants were assessed as having current MDE (MDD group), 15 were fully remitted from at least one prior MDE (rMDD group), and 17 were healthy controls (control group). GABA was assessed at baseline using magnetic resonance spectroscopy in the rostral anterior cingulate cortex and dorsolateral prefrontal cortex. Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-5 diagnosed MDD |
Sample size | 36 |
Tissue | Central; Brain; Rostral anterior cingulate cortex; Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 3 T Siemens MAGNETOM Prisma scanner (Siemens Medical Systems, Iselin, NJ); |
PMID | |
DOI | |
Citation | Ironside M, Moser AD, Holsen LM, et al. Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation. Neuropsychopharmacology. 2021 Aug 6. |
Metabolite |
