Study M777
Study name | Chakraborti A 2021 |
Title | High fructose corn syrup-moderate fat diet potentiates anxio-depressive behavior and alters ventral striatal neuronal signaling |
Overall design | The aim of this study was to evaluate the effects of long-term consumption of a HFCS-Moderate Fat diet (HFCS-MFD) on behavior, neuronal signal transduction, gut microbiota, and serum metabolomic profile in mice to better understand how its consumption and resulting obesity and metabolic alterations relate to behavioral dysfunction. C57Bl/6J mice were divided into the following 2 groups: (1) control group, and (2) HFCS-MFD group. Mice were assigned a control diet or a HFCS-MFD and maintained on each respective diet for 16 weeks. Serum tryptophan metabolites were measured by LC-MS (n = 6/group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57Bl/6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 12 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Chakraborti A, Graham C, Chehade S, et al. High fructose corn syrup-moderate fat diet potentiates anxio-depressive behavior and alters ventral striatal neuronal signaling. Front Neurosci. 2021 May 26;15:669410. |
Metabolite |
