Study M775
Study name | Alhassen S 2021 |
Title | Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction |
Overall design | The aim of this study was to examine the distinctive behavioral impacts and neurobiological mechanisms of in utero exposure alone (prenatal one-hit stress) versus impaired maternal care alone (postnatal one-hit stress) or combined exposure (prenatal and postnatal two-hits stress). Pregnant Swiss Webster mice were divided into the following 2 groups: (1) control group (no stress), and (2) prenatal stress group. On gestational day 17, the pregnant mice in the prenatal stress group were exposed to a predator scent for 1 h on each of four consecutive days in a separate cage under the fume hood and were then returned to their home cage. Male mice were tested from postnatal week 8 to week 13 with a battery of behavioral paradigms. Tissues of one brain hemisphere were collected from adult mice, and metabolic profiling was performed based on a LC-MS platform (n = 5/per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; Swiss Webster mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 10 |
Tissue | Central; Brain; Brain; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Alhassen S, Chen S, Alhassen L, et al. Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction. Commun Biol. 2021 Jun 24;4(1):783. |
Metabolite | myo-Inositol; Glycerol; Oleic acid; Arachidonic acid; L-Aspartic acid; Creatinine; Gluconic acid; Cholesterol; 5'-Methylthioadenosine; Aminoadipic acid; 2-Hydroxyglutarate; Citicoline; 3-Aminoisobutanoic acid; PC(32:1); PC(38:4); PC(38:5); PE(34:2); PE(36:4); PC(32:0); PC(36:2); PG(34:1); PE(38:5); L-Palmitoylcarnitine; LysoPC(20:4); 3-Methylhistidine; PC(36:1); PC(40:5); PE(P-36:2); PE(36:1); PS(38:4); PC(40:7); PS(40:4); PE(34:1); PE(36:2); PC(34:1); PI(36:4); PI(38:5); PC(33:1); TG(46:3); TG(52:3); TG(54:4); TG(56:3); S-Adenosylmethionine; Dihomo-gamma-linolenic acid; LysoPC(17:0/0:0); CE(22:1); TG(54:7); PC(40:8); Erythronic acid lactone; PC(34:4); TG(53:3); TG(51:3); TG(52:4); DG(36:3); D-myo-Inositol 4-phosphate; TG(17:0/17:1/17:0) (d5); MG(17:0/0:0/0:0); DG(18:1/2:0/0:0); PC(12:0/13:0); LysoPE(17:1); SM(d18:1/17:0); BMP 44:12; Cer(d18:1/17:0); Cer(d42:2); PG(17:0/17:0); 5-PAHSA-d9; PC(p-34:0); PC(35:2); PE(p-38:5); PG(44:12); N8-Acetylspermidine; PG(38:4); PE(p-38:3); PS(44:10); FA 22:4; PC(p-34:1); PC(42:5); PC(p-40:6); PE(38:3); PE(36:3e); SM(d36:0); GlcCer(d14:14E/20:02OH); SHexCer d36:1; SHexCer d42:2; PC(34:1e); HexCer-NDS d40:1; |
