Study M759
Study name | Draganov M 2020 |
Title | Glutamatergic and GABA-ergic abnormalities in first-episode depression. a 1-year follow-up 1H-MR spectroscopic study |
Overall design | The aim of this study was to investigate the differences between healthy controls and first episode patients at baseline, together with changes of metabolites after 1 year follow-up in the ventromedial prefrontal cortex. 1H-MRS images were obtained from 63 healthy controls (control group) and 31 first episode depression patients (depression group) using a 3T Philips Achieva scanner at baseline and after 1 year. Examined metabolites included Glx (corresponding to Glu+Gln-peak), Glu, NAAG, myo-Ins, Cr, GSH and GABA. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD, HAMD-17 > 17 |
Sample size | 94 |
Tissue | Central; Brain; Ventromedial prefrontal cortex; |
Platform | MRS; MRS: 3 T Philips Achieva scanner; |
PMID | |
DOI | |
Citation | Draganov M, Vives-Gilabert Y, de Diego-Adelino J, et al. Glutamatergic and GABA-ergic abnormalities in first-episode depression. a 1-year follow-up 1H-MR spectroscopic study. J Affect Disord. 2020 Apr 1;266:572-577. |
Metabolite |
