Study M750
Study name | Tian PJ 2021a |
Title | Unraveling the microbial mechanisms underlying the psychobiotic potential of a Bifidobacterium breve strain |
Overall design | The aim of this study was to investigate the genomic features, metabolic features, and gut microbial and metabolic modulation effect of the psychobiotic strain Bifidobacterium breve CCFM1025 in the chronic unpredictable mild stress (CUMS) model of depression. C57BL/6 mice were divided into the following 2 groups (n = 8 in each group): (1) CUMS group, and (2) CUMS + CCFM1025 group (stressor plus CCFM1025 treatment). The CUMS stress procedure lasted for 6 weeks, and CCFM1025 were administered via intragastric once per day during the model building period. Six fecal samples per group were used for NMR-based metabonomic analysis. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 12 |
Tissue | Peripheral; Faece; Faece; |
Platform | NMR; NMR: Bruker Avance III 600-MHz spectrometer; |
PMID | |
DOI | |
Citation | Tian P, Bastiaanssen TFS, Song L, et al. Unraveling the microbial mechanisms underlying the psychobiotic potential of a Bifidobacterium breve strain. Mol Nutr Food Res. 2021 Feb 16:e2000704. |
Metabolite |
