Study M743
Study name | Shan BX 2020a |
Title | Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway |
Overall design | The aim of this study was to investigate the direct links between the gut microbiome and metabolome and their impact on anxiety, behavior in chronic unpredictable stress (CUS) rats using the combination of microbiome and metabolome analyses. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUS group. The CUS stress procedure lasted for 30 days. Plasma metabolome profile was compared using LC-MS (n = 6 per group). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Forced swimming test, tail suspension test |
Sample size | 12 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: UltiMate 3000 UHPLC system (Thermo Scientific, San Jose, CA, USA) with orbitrap mass spectrometer (LTQ ORBITRAP VELOS PRO, Thermo Fisher Scientific, San Jose, CA, USA); |
PMID | |
DOI | |
Citation | Shan B, Ai Z, Zeng S, et al. Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway. Psychoneuroendocrinology. 2020 Jul;117:104699. |
Metabolite | Cholic acid; Chenodeoxycholic acid; LysoPC(18:2); LysoPE(18:1); LysoPE(22:5); LysoPC(20:4); LysoPE(20:0); PC(16:0); LysoPE(0:0/20:1); Deoxycholic acid 3-glucuronide; LysoPI(20:4(5Z,8Z,11Z,14Z)/0:0); LysoPC(20:3(8Z,11Z,14Z)/0:0); LysoPC(20:3/0:0); 2-Oleoylglycerophosphocholine; SM(d18:0/16:1); Cholesterol sulfate; LysoPC(0:0/18:0); LysoPE(0:0/22:4); 2-Arachidonoylglycerophosphoinositol; 3-Sulfopyruvic acid; 2-Palmitoylglycerophosphocholine; 2-Linoleoyl-sn-glycero-3-phosphocholine; PE(16:0); Desoxylimonin; Tsugaric acid B; Behenoylglycine; TG(15:0); 3a,4b,12a-Trihydroxy-5b-cholanoic acid; MG(0:0/18:3); MG(20:3); MG(0:0/20:5); PC(18:0); PC(18:1/22:5); PC(20:5/16:0); |
