Study M740
Study name | Liu XY 2021 |
Title | Skeletal muscle metabolomic responses to endurance and resistance training in rats under chronic unpredictable mild stress |
Overall design | The aim of this study was to compare the antidepressant effects between two types of exercise, endurance vs. resistance training, for optimizing interventions in a rat model of chronic unpredictable mild stress (CUMS)-induced depression. Sprague-Dawley rats were divided into the following 4 groups (n = 8 in each group): (1) control group, (2) CUMS group, and (3) CUMS + endurance exercise group (stressor plus endurance exercise). The CUMS stress procedure lasted for 4 weeks, and exercise lasted for 4 weeks after stress. The metabolomic changes in the soleus and gastrocnemius muscles in response to the exercise were examined using the 1H-NMR metabolomics technology in combination with the multivariate statistical method. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Peripheral; Muscle; Gastrocnemius muscle; Peripheral; Muscle; Soleus muscle; |
Platform | NMR; NMR: Bruker 600 MHz AVANCE III NMR spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Liu X, Xue X, Tian J, et al. Skeletal muscle metabolomic responses to endurance and resistance training in rats under chronic unpredictable mild stress. Int J Environ Res Public Health. 2021 Feb 9;18(4):1645. |
Metabolite | Citric acid; Glycine; L-Lactic acid; L-Alanine; L-Glutamine; L-Lysine; Choline; Creatinine; Hypoxanthine; Taurine; L-Histidine; Inosine; |
