Study M706
Study name | Tian PJ 2020 |
Title | Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice |
Overall design | The aim of this study was to investigate the effect and probable mechanisms of CCFM1025 psychobiotic treatment on the chronic unpredictable mild stress (CUMS) model of depression. C57BL/6 mice were divided into the following 4 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 10 mg/kg), and (4) CUMS + CCFM1025 group (stressor plus CCFM1025 treatment at the dose of 10^9 CFU). The CUMS stress procedure lasted for 5 weeks, and drugs were administered via intragastric during the model building period. Short-chain fatty acids were extracted by diethyl ether from fresh cecal contents and qualified by GC-MS system (n = 6-8 per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test, tail suspension test |
Sample size | 28 |
Tissue | Peripheral; Faece; Faece; |
Platform | MS-based; GC-MS: TSQ 9000 GC-MS system (Thermo Scientific); |
PMID | |
DOI | |
Citation | Tian P, O'Riordan KJ, Lee YK, et al. Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice. Neurobiol Stress. 2020;12:100216. |
Metabolite |
