Study M704
Study name | Munkboel CH 2018 |
Title | Sertraline suppresses testis and adrenal steroid production and steroidogenic gene expression while increasing LH in plasma of male rats resulting in compensatory hypogonadism |
Overall design | The aim of this study was to investigate the possible endocrine disrupting effect of sertraline on sex steroid production in male rats exposed to 3 therapeutically realistic doses of sertraline 1.25, 5, and 20 mg/kg/day. Sprague-Dawley rats were divided into the following 4 groups: (1) control group (n = 12), (2) low dose of sertraline group (sertraline treatment at the dose of 1.25 mg/kg, n = 6), (3) middle dose of sertraline group (sertraline treatment at the dose of 5 mg/kg, n = 6), and (4) high dose of sertraline group (sertraline treatment at the dose of 20 mg/kg, n = 6). Drugs were administered via food once daily for 2 weeks. Testis, adrenals, plasma, and brain samples were to measure steroid productions. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 30 |
Tissue | Peripheral; Adrenal gland; Adrenal gland; Peripheral; Testis; Testis; Peripheral; Blood; Plasma; Central; Brain; Brain; |
Platform | MS-based; LC-MS: 1290 Aglient infinity series system with mass spectrometer (AB SCIEX 4500 QTRAP); |
PMID | |
DOI | |
Citation | Munkboel CH, Larsen LW, Weisser JJ, et al. Sertraline suppresses testis and adrenal steroid production and steroidogenic gene expression while increasing LH in plasma of male rats resulting in compensatory hypogonadism. Toxicol Sci. 2018;163(2):609-619. |
Metabolite | Androstenedione; Corticosterone; Pregnenolone; Progesterone; Testosterone; 5-Androstenediol; |
