Study M699

Study name

Achtyes E 2020

Title

Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression

Overall design

The aim of this study was to investigate whether a pro-inflammatory status in plasma, together with changes in the kynurenine pathway activity, is associated with the development of severe depression and suicidal behavior in the post-partum. Post-partum women with depression (depression group, n = 87) and healthy controls (control group, n = 60) were recruited. Quinolinic acid was analyzed using gas chromatography-mass spectrometry. Ultra-high performance liquid chromatography, coupled to tandem mass spectrometry was used to determine plasma serotonin, kynurenic acid and nicotinic acid concentrations.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Postpartum depression; Postpartum depression;

Criteria for depression

DSM-5 diagnosed postpartum depression

Sample size

147

Tissue

Peripheral; Blood; Plasma;

Platform

MS-based; LC-MS: Waters Acquity UPLC and Waters Acquity TQ-D mass spectrometer;

MS-based; GC-MS: not reported;

PMID

31698012

DOI

10.1016/j.bbi.2019.10.017

Citation

Achtyes E, Keaton SA, Smart L, et al. Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression. Brain Behav Immun. 2020;83:239-247.

Metabolite

Serotonin;

Quinolinic acid;