Study M682
Study name | Zhang H 2020 |
Title | A metabolomic study on the gender-dependent effects of maternal exposure to fenvalerate on neurodevelopment in offspring mice |
Overall design | The aim of this study was to identify the effects of maternal exposure to fenvalerate on neurodevelopment in offspring mice. Pregnant ICR mice were randomly divided into 2 groups, including the control group and the fenvalerate group (fenvalerate 30 mg/kg/day, gavage, from D8 to D18 during pregnancy). Thirty-five-day old ICR offsprings (fenvalerate-treated offspring group and control offspring group, male: female = 1: 1) were tested for forced swimming test. Serum and thyroid samples were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; ICR mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 12 |
Tissue | Peripheral; Thyroid; Thyroid; Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: UltiMate3000 high-performance liquid chromatography system (Dionex, Germering, Germany) coupled with the Q-Exactive mass spectrometer (Thermo Fisher Scientific, Bremen, Germany); |
PMID | |
DOI | |
Citation | Zhang H, Lu T, Feng Y, et al. A metabolomic study on the gender-dependent effects of maternal exposure to fenvalerate on neurodevelopment in offspring mice. Sci Total Environ. 2020;707:136130. |
Metabolite | L-Glutamic acid; L-Aspartyl-L-phenylalanine; Xanthurenic acid; Glucose 6-phosphate; Taurine; Xanthosine; 5'-Methylthioadenosine; Adenosine; Cytidine; Rhamnose; Cortisol; Folic acid; Thiamine; Gluconolactone; Dodecanoic acid; Capric acid; N-Acetylneuraminic acid; 1-Palmitoyl-palmitoyl; |
