Study M670
Study name | Xie XX 2020b |
Title | Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice |
Overall design | The aim of this study was to investigate the antidepressant mechanism of action of nicotinamide mononucleotide. C57/BL6 mice were divided into the following 3 groups (n = 8 in each group): (1) control group, (2) corticosterone group (corticosterone administered subcutaneously daily at the dose of 20 mg/kg for 6 weeks), and (3) corticosterone + nicotinamide mononucleotide group (corticosterone administration for 6 weeks, with nicotinamide mononucleotide treatment in the last 2 weeks, at the dose of 300 mg/kg, oral gavage). Six liver samples per group were used for metabonomic analysis. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Mouse; C57/BL6 mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Tail suspension test, forced swimming test |
Sample size | 12 |
Tissue | Peripheral; Liver; Liver; |
Platform | MS-based; GC-MS: Agilent 7890 gas chromatograph-Leco Pegasus HT time-of-flight mass spectrometer; |
PMID | |
DOI | |
Citation | Xie X, Yu C, Zhou J, et al. Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice. J Affect Disord. 2020;263:166-174. |
Metabolite | Oleic acid; Arachidonic acid; Taurine; Adenosine; Glutathione; |
