Study M665
Study name | Wu M 2020 |
Title | Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice |
Overall design | The aim of this study was to explore the associations between changes in neurotransmitters and short-chain fatty acids (SCFAs) and altered gut microbiota in the chronic restraint stress (CRS) model of depression. C57BL/6 mice were divided into the following 2 groups: (1) control group, and (2) CRS group (restraint stress for 28 days). Liquid and gas chromatography mass spectroscopy were used to identify neurotransmitters in hypothalamus and SCFAs in fecal samples, respectively. Ten samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic restraint stress model; Chronic restraint stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 20 |
Tissue | Central; Brain; Hypothalamus; Peripheral; Faece; Faece; |
Platform | MS-based; LC-MS: Agilent 1290 HPLC system with 5500 QTRAP mass spectrometer (AB SCIEX); MS-based; GC-MS: 5977B GC/MSD; |
PMID | |
DOI | |
Citation | Wu M, Tian T, Mao Q, et al. Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice. Transl Psychiatry. 2020;10(1):350. |
Metabolite |
