Study M649
Study name | Nie LJ 2021a |
Title | A UPLC-MS/MS method for determination of endogenous L-carnitine and Acetyl-L-carnitine in serum of patients with depression |
Overall design | In this study, a simple, rapid and selective ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for determination of L-carnitine (LC) and Acetyl-L-carnitine (ALC) in human serum was developed. This method was successfully applied to study the concentrations of endogenous LC and ALC in the serum of patients with first-episode depression (depression group, n = 100) and healthy controls (control group, n = 100). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | Not reported |
Sample size | 200 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Waters Acquity ultra performance liquid chromatography (UPLC) coupled to Waters Xevo TQ-S mass spectrometer; |
PMID | |
DOI | |
Citation | Nie LJ, Liang J, Shan F, et al. A UPLC-MS/MS method for determination of endogenous L-carnitine and Acetyl-L-carnitine in serum of patients with depression. Biomedical Chromatography. 2021 Mar;35(3):e4991. |
Metabolite |
