Study M622
Study name | Kochalska K 2020 |
Title | Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress |
Overall design | The aim of this study was to identify neurometabolic changes relating to depression and Lactobacillus rhamnosus JB-1 treatment using magnetic resonance spectroscopy (MRS). A rat model of depressive-like disorder, chronic unpredictable mild stress (CUMS), was used. Wistar rats were divided into the following 2 groups: (1) control group (no stress), and (2) CUMS group (stress for 5 weeks). Then rats in the CUMS group were divided in to Lactobacillus rhamnosus JB-1 supplementation group (CUMS + JB-1 group) or placebo group (CUMS + placebo group). The CUMS stress procedure lasted for 5 weeks, and the microbiotic diet were administered for 4 weeks after stress. MRS was performed before and after JB-1 treatment. Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 45 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 7 T MRI scanner (70/16 Pharma Scan, Bruker Biospin, GmbH, Germany); |
PMID | |
DOI | |
Citation | Kochalska K, Oakden W, Slowik T, et al. Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. Nutr Res. 2020;82:44-57. |
Metabolite | Gamma-Aminobutyric acid; N-Acetyl-L-aspartic acid; L-Glutamic acid; |
