Study M619
Study name | Jiao ZY 2021 |
Title | An investigation of the antidepressant-like effect of Jiaotaiwan in rats by nontargeted metabolomics based on ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry |
Overall design | The aim of this study was to investigate the anti-depressive effect of Jiaotaiwan in chronic unpredictable mild stress (CUMS)-induced rat models and demonstrate the potential biomarkers and relevant metabolic pathways. Sprague-Dawley rats were divided into the following 6 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine treatment at the dose of 7.5 mg/kg), (4) CUMS + low dose of Jiaotaiwan group (stressor plus Jiaotaiwan treatment at the dose of 0.75 g/kg), (5) CUMS + middle dose of Jiaotaiwan group (stressor plus Jiaotaiwan treatment at the dose of 1.5 g/kg), and (6) CUMS + high dose of Jiaotaiwan group (stressor plus Jiaotaiwan treatment at the dose of 3 g/kg). The CUMS stress procedure lasted for 5 weeks, and drugs were administered via intragastric once per day during the last 2 weeks of the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 60 |
Tissue | Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: UPLC-Q-TOF/MS system (Waters, USA); |
PMID | |
DOI | |
Citation | Jiao Z, Zhao H, Huang W, et al. An investigation of the antidepressant-like effect of Jiaotaiwan in rats by nontargeted metabolomics based on ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry. J Sep Sci. 2021 Jan;44(2):645-655. |
Metabolite | myo-Inositol; L-Tryptophan; D-Glucose; Indoleacrylic acid; |
