Study M616
Study name | He Y 2020 |
Title | Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive rats |
Overall design | In this study, we conducted the non-targeted metabolomics method based on gas chromatography-mass spectrometry (GC-MS) coupled with multivariate statistical analysis to characterize the differential metabolites in olfactory bulb of chronic unpredictable mild stress (CUMS) rats. Sprague-Dawley rats were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. Nine olfactory bulb samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Central; Brain; Olfactory bulb; |
Platform | MS-based; GC-MS: Agilent 7890A/5975C system (Agilent Technologies Inc., USA); |
PMID | |
DOI | |
Citation | He Y, Wang Y, Wu Z, et al. Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive rats. Metab Brain Dis. 2020;35(4):649-659. |
Metabolite | Glyceric acid; Oleic acid; N-Acetyl-L-aspartic acid; Arachidonic acid; L-Aspartic acid; Docosahexaenoic acid; Inosine; Glycolic acid; Adenine; Ribitol; Guanosine; Glycerol-1,3-diphosphate; myo-Inositol 6-phosphate; Desmosterol; |
