Study M615
Study name | Hassan AM 2022 |
Title | Anhedonia induced by high-fat diet in mice depends on gut microbiota and leptin |
Overall design | The aim of this study was to examine the role of the intestinal microbiota and the adipocytokine leptin as potential mediators of the effects of high-fat diet to induce anhedonia-like behavior and reduce self-care in mice. C57BL/6J mice were divided into the following 4 groups: (1) control group (control diet for 4 weeks), (2) high-fat diet group (high-fat diet for 4 weeks), (3) antibiotics group (control diet plus antibiotics treatment for 4 weeks), and (4) high-fat diet + antibiotics group (stressor plus antibiotics treatment for 4 weeks). High-fat diet group showed decreased sucrose preference than control group, while high-fat diet + antibiotics group showed increased sucrose preference than high-fat diet group. Eight to ten cecal content samples per group were used for NMR-based metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57BL/6J mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 38 |
Tissue | Peripheral; Faece; Faece; |
Platform | NMR; NMR: Bruker AV700 NMR Spectrometer; |
PMID | |
DOI | |
Citation | Hassan AM, Mancano G, Kashofer K, et al. Anhedonia induced by high-fat diet in mice depends on gut microbiota and leptin. Nutr Neurosci. 2022 Feb;25(2):299-312. |
Metabolite |
