Study M610
Study name | Geng CM 2020b |
Title | Systematic impacts of chronic unpredictable mild stress on metabolomics in rats |
Overall design | The aim of this study was to provide a panoramic and systematic view of metabolic alterations in stress-targeted tissues (serum, heart, liver, brain, and kidney) in the context of the chronic unpredictable mild stress (CUMS)-induced rat model of depression. Sprague-Dawley rats were divided into the following 2 groups (n = 8 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 16 |
Tissue | Peripheral; Heart; Heart; Peripheral; Liver; Liver; Peripheral; Blood; Serum; Central; Brain; Brain; Peripheral; Kidney; Kidney; |
Platform | MS-based; GC-MS: 7890B GC system with 7000C mass spectrometer; |
PMID | |
DOI | |
Citation | Geng C, Guo Y, Wang C, et al. Systematic impacts of chronic unpredictable mild stress on metabolomics in rats. Sci Rep. 2020;10(1):700. |
Metabolite | Linoleic acid; Stearic acid; 3-Hydroxybutyric acid; Myristic acid; Palmitoleic acid; Palmitic acid; L-Phenylalanine; L-Valine; L-Glutamic acid; Glycine; L-Serine; L-Threonine; L-Isoleucine; L-Methionine; L-Alanine; Oxalic acid; |
