Study M599
Study name | Deligiannidis KM 2020 |
Title | Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: a liquid chromatography-tandem mass spectrometry analysis |
Overall design | The aim of this study was to examine a panel of plasma proneuroactive and neuroactive steroids (NAS) in perinatal women at-risk for perinatal depression (AR-PND, n = 19) compared to healthy perinatal comparison women (control group, n = 30) and compared to AR-PND women who developed adjustment disorders/minor/major depression (PND group, n = 26). Antenatal and postnatal plasma concentrations of proneuroactive steroids (pregnenolone, progesterone, 5alpha-dihydroprogesterone, 5beta-dihydroprogesterone, allopregnanolone, pregnanolone and tetrahydrodeoxycorticosterone) were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Postpartum depression; Postpartum depression; |
Criteria for depression | DSM-IV diagnosed major depression or minor depression or adjustment disorder with depressed mood |
Sample size | 56 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: NanoAcquity UPLC (Waters Corporation, Milford, MA) with Orbitrap Velos Pro (Thermo Scientific, Waltham, MA) mass spectrometer; |
PMID | |
DOI | |
Citation | Deligiannidis KM, Kroll-Desrosiers AR, Tan Y, et al. Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: a liquid chromatography-tandem mass spectrometry analysis. Psychoneuroendocrinology. 2020;121:104827. |
Metabolite | Allopregnanolone; |
