Study M591
Study name | Chan SY 2020 |
Title | Post-inflammatory behavioural despair in male mice is associated with reduced cortical glutamate-glutamine ratios, and circulating lipid and energy metabolites |
Overall design | The aims of this study were to confirm that peripherally administered lipopolysaccharide (LPS) has central effects on brain inflammatory markers and increases depressive-like behaviour after 24 h in mice, and to determine what are the plasma and brain metabolite profiles that accompany the behavioural changes. CD-1 mice were divided into the following 2 groups: (1) control group, and (2) LPS group (a single intraperitoneal injection of LPS at the dose of 0.83 mg/kg). Plasma, prefrontal cortex and hippocampus tissues were collected for NMR-based metabolomics analysis. A total of 14-15 mice per group were used in the analyses of metabolomic data. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; CD-1 mouse; |
Categories of depression | Animal model; Lipopolysaccharide induced depression model; Lipopolysaccharide induced depression model; |
Criteria for depression | Forced swimming test |
Sample size | 29 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; Peripheral; Blood; Plasma; |
Platform | NMR; NMR: 700-MHz Bruker AVII spectrometer; |
PMID | |
DOI | |
Citation | Chan SY, Probert F, Radford-Smith DE, et al. Post-inflammatory behavioural despair in male mice is associated with reduced cortical glutamate-glutamine ratios, and circulating lipid and energy metabolites. Sci Rep. 2020;10(1):16857. |
Metabolite | Glycerol; N-Acetyl-L-aspartic acid; L-Glutamic acid; L-Serine; L-Isoleucine; L-Alanine; L-Glutamine; |
