Study M589
Study name | Bot M 2020 |
Title | Metabolomics profile in depression: a pooled analysis of 230 metabolic markers in 5283 cases with depression and 10,145 controls |
Overall design | In this study, nine Dutch cohorts were included, comprising 10,145 control subjects and 5283 persons with depression, established with diagnostic interviews or questionnaires. A proton nuclear magnetic resonance metabolomics platform provided 230 metabolite measures: 51 lipids, fatty acids, and low-molecular-weight metabolites; 98 lipid composition and particle concentration measures of lipoprotein subclasses; and 81 lipid and fatty acids ratios. In 62% of the cases (3265 subjects), depression was present between 1 month before and 1 month after blood draw. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom; Depressive symptom; |
Criteria for depression | Diagnosed MDD or depression rating scale |
Sample size | 13410 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Bruker AVANCE IIIHD NMR spectrometer; |
PMID | |
DOI | |
Citation | Bot M, Milaneschi Y, Al-Shehri T, et al. Metabolomics profile in depression: a pooled analysis of 230 metabolic markers in 5283 cases with depression and 10,145 controls. Biol Psychiatry. 2020;87(5):409-418. |
Metabolite | Citric acid; L-Isoleucine; Acetic acid; Glycoprotein acetyls; Mean diameter for VLDL particles; VLDL triglycerides; Serum total triglycerides; VLDL cholesterol; Triglycerides in HDL; Monounsaturated fatty acids; Remnant cholesterol; Apolipoprotein B; Diglycerides; Total fatty acids; Saturated fatty acids; LDL triglycerides; Total cholesterol in HDL3; Estimated degree of unsaturation; |
