Study M563
Study name | Qu W 2019 |
Title | Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function |
Overall design | In this study, a randomized, controlled trial was conducted to examine the impact of stress on gut microbiota dysbiosis and depression, and traditional Chinese medicine (TCM) in alleviating the damage using chronic unpredictable mild stress (CUMS) rats, a well-established rodent model for depression. Sprague-Dawley rats were divided into the following 3 groups: (1) control group, (2) CUMS group, and (3) CUMS + TCM group (stressor plus TCM treatment). The CUMS stress procedure lasted for 8 weeks, and drugs were administered for 6 weeks after stress. Data on brain targeted metabolites by liquid chromatography-mass spectrometry (LC-MS) were discussed. Five samples per group were used for metabonomic analysis. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 15 |
Tissue | Central; Brain; Brain; |
Platform | MS-based; LC-MS: AB Sciex Ultra high Performance LC system with AB Sciex Triple TOF 5600+ (Analyst TF 1.7, AB Sciex) TOF mass spectrometer; |
PMID | |
DOI | |
Citation | Qu W, Liu S, Zhang W, et al. Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function. Food Funct. 2019;10(9):5886-5897. |
Metabolite |
