Study M552
Study name | Liu SB 2019 |
Title | [1H-NMR metabolomics analysis of changes of serum metabolites in rats with depression induced by Compound Chaigui Prescription] |
Overall design | The aim of this study was to analyze the effect of Compound Chaigui Prescription on the changes of serum metabolites in rats with depression by 1H-NMR metabolomics. Sprague-Dawley rats were divided into the following 7 groups (n = 8 in each group): (1) control group, (2) CUMS group, (3) CUMS + venlafaxine group (stressor plus venlafaxine treatment at the dose of 35 mg/kg), (4) CUMS + low dose of Chaigui group (stressor plus Chaigui treatment at the dose of 4.8 g/kg), (5) CUMS + median dose of Chaigui group (stressor plus Chaigui treatment at the dose of 9.7 g/kg), (6) CUMS + high dose of Chaigui group (stressor plus Chaigui treatment at the dose of 19.4 g/kg), and (7) CUMS + augmentation treatment group (stressor plus venlafaxine and Chaigui treatment). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via intragastric during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 56 |
Tissue | Peripheral; Blood; Serum; |
Platform | NMR; NMR: Bruker 600 MHz AVANC III spectrometer; |
PMID | |
DOI | |
Citation | Liu SB, Xu T, Gao Y, et al. [1H-NMR metabolomics analysis of changes of serum metabolites in rats with depression induced by Compound Chaigui Prescription]. Chinese Traditional and Herbal Drugs. 2019;50(1):97-103. (Article in Chinese) |
Metabolite |
